Version 5.4
Homo sapiens Gene: IRF9
Summary
InnateDB Gene IDBG-236583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF9
Gene Name interferon regulatory factor 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213928
Encoded Proteins
IDBP-3589
interferon regulatory factor 9
IDBP-236585
interferon regulatory factor 9
IDBP-591388
interferon regulatory factor 9
IDBP-599523
interferon regulatory factor 9
IDBP-599669
interferon regulatory factor 9
IDBP-594614
interferon regulatory factor 9
IDBP-595105
interferon regulatory factor 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9242679
IRF9 is a DNA-binding protein that is a member of the alpha-interferon-induced ISGF3 complex. Bipartite complexes of STAT2:IRF9 and STAT2:STAT1 translocate to the nucleus and associate on DNA target sites as ISGF3.
PMID 15194680
IRF9 functions to recruit RNA polymerase II to the promoter of interferon (IFN)-stimulated genes and this function of IRF9 requires the activity of histone deacetylases.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24161053-24166565
Strand Forward strand
Band q12
Transcripts
ENST00000324076 ENSP00000313529
ENST00000396864 ENSP00000380073
ENST00000557894 ENSP00000453534
ENST00000561342 ENSP00000453974
ENST00000561009
ENST00000560365
ENST00000561415
ENST00000559284 ENSP00000453540
ENST00000560275 ENSP00000454095
ENST00000561412
ENST00000560852 ENSP00000454078
ENST00000559863
ENST00000559229
ENST00000560542
ENST00000560311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 31 [view]
Protein-DNA 31 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007166 cell surface receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045351 type I interferon biosynthetic process
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002325
View Gene Order
ENSBTAG00000005816
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IFN alpha signaling pathway
PID NCI
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1706
RefSeq NM_006084
HUGO
OMIM
CCDS CCDS9615
HPRD 00960
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca