Version 5.4
Homo sapiens Gene: KLRK1
Summary
InnateDB Gene IDBG-237489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRK1
Gene Name killer cell lectin-like receptor subfamily K, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213809
Encoded Proteins
IDBP-18875
killer cell lectin-like receptor subfamily K, member 1
IDBP-237491
killer cell lectin-like receptor subfamily K, member 1
IDBP-602639
killer cell lectin-like receptor subfamily K, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10372353-10391874
Strand Reverse strand
Band p13.2
Transcripts
ENST00000240618 ENSP00000240618
ENST00000396451 ENSP00000379726
ENST00000540267
ENST00000544449
ENST00000540818 ENSP00000446003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007165 signal transduction
GO:0030101 natural killer cell activation
GO:0030154 cell differentiation
GO:0031295 T cell costimulation
GO:0045087 innate immune response
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030149
View Gene Order
ENSBTAG00000004917
Not yet available
Pathways
NETPATH
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8WZ67
UniProt Splice Variant
Entrez Gene 22914
UniGene Hs.387787
RefSeq NM_007360
HUGO HGNC:18788
OMIM 611817
CCDS CCDS8623
HPRD 17240
IMGT
EMBL AC022075 AF439512
GenPept AAL35226
RNA Seq Atlas 100528032 22914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca