Homo sapiens Gene: ADAMTS6
Summary
InnateDB Gene IDBG-23823.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS6
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 6
Synonyms ADAM-TS 6; ADAM-TS6; ADAMTS-6
Species Homo sapiens
Ensembl Gene ENSG00000049192
Encoded Proteins
ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65148736-65481920
Strand Reverse strand
Band q12.3
Transcripts
ENST00000381055 ENSP00000370443
ENST00000381052 ENSP00000424377
ENST00000314351
ENST00000417396
ENST00000470597
ENST00000464680
ENST00000504282
ENST00000502886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.482291
RefSeq NM_197941
HUGO
OMIM
CCDS CCDS3983
HPRD 05421
IMGT
EMBL
GenPept
RNA Seq Atlas