InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS29

Summary

InnateDB Gene

IDBG-238371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS29

Gene Name

ribosomal protein S29

Synonyms

DBA13; S29

Species

Homo sapiens

Ensembl Gene

ENSG00000213741

Encoded Proteins

IDBP-5652

ribosomal protein S29

IDBP-238373

ribosomal protein S29

IDBP-812735

ribosomal protein S29

IDBP-812737

ribosomal protein S29

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:49570984-49599164

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000245458	ENSP00000245458
ENST00000396020	ENSP00000379339
ENST00000557367
ENST00000557111	ENSP00000478117
ENST00000554075
ENST00000557519
ENST00000556230
ENST00000611563	ENSP00000479892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	53 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0008270	zinc ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome