Homo sapiens Gene: NRG4
Summary
InnateDB Gene IDBG-23842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRG4
Gene Name neuregulin 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169752
Encoded Proteins
neuregulin 4
neuregulin 4
neuregulin 4
neuregulin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75935969-76059795
Strand Reverse strand
Band q24.2
Transcripts
ENST00000394907 ENSP00000378367
ENST00000461391 ENSP00000431810
ENST00000472094 ENSP00000432751
ENST00000498750 ENSP00000436832
ENST00000568073 ENSP00000456778
ENST00000567467
ENST00000563582
ENST00000566417 ENSP00000457335
ENST00000567936 ENSP00000456029
ENST00000563910 ENSP00000455167
ENST00000565661 ENSP00000457838
ENST00000563204 ENSP00000455314
ENST00000568203
ENST00000569343
ENST00000562114 ENSP00000454895
ENST00000567126 ENSP00000457626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
G-secretase mediated erbb4 signaling pathway [Biocarta view]
PID NCI
ErbB4 signaling events
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL H3BP63 Q68D87
UniProt Splice Variant
Entrez Gene 145957
UniGene Hs.602228 Hs.696574 Hs.732438 Hs.739542
RefSeq NM_138573
HUGO HGNC:29862
OMIM 610894
CCDS CCDS10288
HPRD 14871
IMGT
EMBL AC027104 AC087456 AC091100 CR749519
GenPept CAH18333
RNA Seq Atlas 145957