Version 5.4
Homo sapiens Gene: TREX1
Summary
InnateDB Gene IDBG-239077.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREX1
Gene Name three prime repair exonuclease 1
Synonyms AGS1; CRV; DRN3; HERNS
Species Homo sapiens
Ensembl Gene ENSG00000213689
Encoded Proteins
IDBP-32708
three prime repair exonuclease 1
IDBP-376010
three prime repair exonuclease 1
IDBP-376013
three prime repair exonuclease 1
IDBP-376016
three prime repair exonuclease 1
IDBP-376021
three prime repair exonuclease 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
This gene encodes a nuclear protein with 3\' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48465046-48467645
Strand Forward strand
Band p21.31
Transcripts
ENST00000296443 ENSP00000296443
ENST00000395677
ENST00000433541 ENSP00000412404
ENST00000444177 ENSP00000415972
ENST00000456089 ENSP00000411331
ENST00000436480 ENSP00000392569
ENST00000492235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0032558 adenyl deoxyribonucleotide binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0008219 cell death
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0035458 cellular response to interferon-beta
GO:0045087 innate immune response
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005730 nucleolus
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049734
View Gene Order
ENSBTAG00000008406
Not yet available
Pathways
NETPATH
REACTOME
REACT_147841
STING mediated induction of host immune responses pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_6802
Innate Immune System pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_6900
Immune System pathway
REACT_163652
Regulation by TREX1 pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.707026 Hs.713742 Hs.743501
RefSeq NM_007248 NM_016381 NM_033629 NM_001271022 NM_001271023 NM_032166 NM_130384
HUGO
OMIM
CCDS CCDS2769 CCDS59451 CCDS2767 CCDS2768 CCDS59449 CCDS59450
HPRD 09423
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca