Version 5.4
Homo sapiens Gene: LRRC8E
Summary
InnateDB Gene IDBG-23957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC8E
Gene Name leucine rich repeat containing 8 family, member E
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171017
Encoded Proteins
IDBP-23959
leucine rich repeat containing 8 family, member E
IDBP-763789
IDBP-759789
IDBP-765370
IDBP-764330
IDBP-808063
leucine rich repeat containing 8 family, member E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7888505-7902021
Strand Forward strand
Band p13.2
Transcripts
ENST00000306708 ENSP00000306524
ENST00000598224 ENSP00000470302
ENST00000600345 ENSP00000473127
ENST00000599367 ENSP00000472491
ENST00000593511 ENSP00000472642
ENST00000618098 ENSP00000479953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046589
View Gene Order
ENSBTAG00000004300
Not yet available
Cross-References
SwissProt
TrEMBL M0R2K8
UniProt Splice Variant
Entrez Gene 80131
UniGene Hs.692085 Hs.743594
RefSeq NM_001268284 NM_001268285 NM_025061 XM_005272497
HUGO HGNC:26272
OMIM 612891
CCDS CCDS12189
HPRD 08670
IMGT
EMBL AC010336
GenPept
RNA Seq Atlas 80131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca