Homo sapiens Gene: MAP2K7
Summary
InnateDB Gene IDBG-24000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K7
Gene Name mitogen-activated protein kinase kinase 7
Synonyms JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4;
Species Homo sapiens
Ensembl Gene ENSG00000076984
Encoded Proteins
mitogen-activated protein kinase kinase 7
mitogen-activated protein kinase kinase 7
mitogen-activated protein kinase kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9
Entrez Gene
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7903843-7914478
Strand Forward strand
Band p13.2
Transcripts
ENST00000397983 ENSP00000381070
ENST00000397981 ENSP00000381068
ENST00000397979 ENSP00000381066
ENST00000468058
ENST00000475022
ENST00000494348
ENST00000465324
ENST00000498118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 56 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008545 JUN kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051403 stress-activated MAPK cascade
GO:0072709 cellular response to sorbitol
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TNFalpha pathway
IL1 pathway
RANKL pathway
REACTOME
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Uptake and actions of bacterial toxins pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Cellular Senescence pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Uptake and function of anthrax toxins pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
GnRH signaling pathway pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Keratinocyte differentiation [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Reelin signaling pathway
Cellular roles of Anthrax toxin
TNF receptor signaling pathway
RAC1 signaling pathway
CDC42 signaling events
Fc-epsilon receptor I signaling in mast cells
HIV-1 Nef: Negative effector of Fas and TNF-alpha
FAS (CD95) signaling pathway
Cross-References
SwissProt O14733
TrEMBL D6W660
UniProt Splice Variant
Entrez Gene 5609
UniGene Hs.531754 Hs.669393
RefSeq NM_001297555 NM_001297556 NM_145185 XM_005272489 XM_005272490 XM_006722800
HUGO HGNC:6847
OMIM 603014
CCDS CCDS42491 CCDS74277 CCDS74278
HPRD
IMGT
EMBL AF003199 AF006689 AF013588 AF013589 AF014401 AF022805 AK313899 BC038295 CH471139 DQ445915
GenPept AAB63374 AAB88048 AAB97813 AAC16272 AAC16273 AAC26142 AAH38295 ABE03013 BAG36622 EAW68963 EAW68964 EAW68967 EAW68968
RNA Seq Atlas 5609