Version 5.4
Homo sapiens Gene: CRTAP
Summary
InnateDB Gene IDBG-24026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTAP
Gene Name cartilage associated protein
Synonyms CASP; LEPREL3; OI7
Species Homo sapiens
Ensembl Gene ENSG00000170275
Encoded Proteins
IDBP-24030
cartilage associated protein
IDBP-369908
cartilage associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:33113979-33147773
Strand Forward strand
Band p22.3
Transcripts
ENST00000320954 ENSP00000323696
ENST00000449224 ENSP00000409997
ENST00000485310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005351 sugar:proton symporter activity
GO:0032403 protein complex binding
Biological Process
GO:0006810 transport
GO:0007283 spermatogenesis
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline
GO:0030198 extracellular matrix organization
GO:0050821 protein stabilization
GO:0061077 chaperone-mediated protein folding
GO:1901874 negative regulation of post-translational protein modification
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0032991 macromolecular complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032431
View Gene Order
ENSBTAG00000021442
Not yet available
Pathways
NETPATH
REACTOME
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JP16
UniProt Splice Variant
Entrez Gene 10491
UniGene Hs.517888 Hs.728073 Hs.737987
RefSeq NM_006371
HUGO HGNC:2379
OMIM 605497
CCDS CCDS2657
HPRD 16110
IMGT
EMBL AC112211 AC123900
GenPept
RNA Seq Atlas 10491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca