Version 5.4
Homo sapiens Gene: RCN2
Summary
InnateDB Gene IDBG-24088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCN2
Gene Name reticulocalbin 2, EF-hand calcium binding domain
Synonyms E6BP; ERC-55; ERC55; TCBP49
Species Homo sapiens
Ensembl Gene ENSG00000117906
Encoded Proteins
IDBP-24090
reticulocalbin 2, EF-hand calcium binding domain
IDBP-240670
reticulocalbin 2, EF-hand calcium binding domain
IDBP-240672
reticulocalbin 2, EF-hand calcium binding domain
IDBP-601899
reticulocalbin 2, EF-hand calcium binding domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76931619-76954392
Strand Forward strand
Band q24.3
Transcripts
ENST00000320963 ENSP00000319739
ENST00000394885 ENSP00000378349
ENST00000394883 ENSP00000378347
ENST00000557805 ENSP00000453052
ENST00000558598
ENST00000560833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032320
View Gene Order
ENSBTAG00000015780
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5955
UniGene Hs.79088
RefSeq NM_001271837 NM_002902
HUGO HGNC:9935
OMIM 602584
CCDS CCDS10291 CCDS61719
HPRD 03993
IMGT
EMBL
GenPept
RNA Seq Atlas 5955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca