InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PF4

Summary

InnateDB Gene

IDBG-24097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PF4

Gene Name

platelet factor 4

Synonyms

CXCL4; PF-4; SCYB4

Species

Homo sapiens

Ensembl Gene

ENSG00000163737

Encoded Proteins

IDBP-24099

platelet factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:73981077-73982124

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000296029

ENSP00000296029

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002576	platelet degranulation
GO:0006955	immune response
GO:0007596	blood coagulation
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0030595	leukocyte chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045651	positive regulation of macrophage differentiation
GO:0045653	negative regulation of megakaryocyte differentiation
GO:0045918	negative regulation of cytolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand