Homo sapiens Gene: AREG
Summary
InnateDB Gene IDBG-24392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AREG
Gene Name amphiregulin
Synonyms AR; AREGB; CRDGF; SDGF;
Species Homo sapiens
Ensembl Gene ENSG00000109321
Encoded Proteins
amphiregulin
amphiregulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74445134-74455009
Strand Forward strand
Band q13.3
Transcripts
ENST00000395748 ENSP00000379097
ENST00000502307 ENSP00000421414
ENST00000511560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0014009 glial cell proliferation
GO:0014070 response to organic cyclic compound
GO:0031175 neuron projection development
GO:0032355 response to estradiol
GO:0042327 positive regulation of phosphorylation
GO:0042542 response to hydrogen peroxide
GO:0043434 response to peptide hormone
GO:0045668 negative regulation of osteoblast differentiation
GO:0045740 positive regulation of DNA replication
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744 mammary gland branching involved in thelarche
GO:0060749 mammary gland alveolus development
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
ErbB signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
ErbB receptor signaling network
Cross-References
SwissProt P15514
TrEMBL
UniProt Splice Variant
Entrez Gene 374
UniGene Hs.270833
RefSeq NM_001657
HUGO HGNC:651
OMIM 104640
CCDS CCDS3565
HPRD 00093
IMGT
EMBL AY442340 BC009799 BC146953 BC146967 BT019866 CH471057 M30698 M30699 M30700 M30701 M30702 M30704
GenPept AAA51773 AAA51781 AAH09799 AAI46954 AAI46968 AAR05438 AAV38669 EAX05710
RNA Seq Atlas 374