Homo sapiens Gene: IDH3A
Summary
InnateDB Gene IDBG-24462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH3A
Gene Name isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166411
Encoded Proteins
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78131498-78171949
Strand Forward strand
Band q25.1
Transcripts
ENST00000299518 ENSP00000299518
ENST00000558605
ENST00000558933 ENSP00000452620
ENST00000558554 ENSP00000453084
ENST00000560667 ENSP00000453033
ENST00000557826 ENSP00000453480
ENST00000561279 ENSP00000453747
ENST00000559186 ENSP00000452754
ENST00000560396 ENSP00000453192
ENST00000560770 ENSP00000453903
ENST00000559865 ENSP00000453438
ENST00000559881 ENSP00000453222
ENST00000558509 ENSP00000453992
ENST00000559889
ENST00000559803 ENSP00000453338
ENST00000559205 ENSP00000453989
ENST00000560414
ENST00000559106 ENSP00000453008
ENST00000558602
ENST00000558535
ENST00000561366 ENSP00000453795
ENST00000558016
ENST00000557960 ENSP00000453459
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Citrate cycle (TCA cycle) pathway
INOH
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YNF8
UniProt Splice Variant
Entrez Gene 3419
UniGene Hs.250616 Hs.595357 Hs.604929 Hs.659780
RefSeq NM_005530 XM_005254336
HUGO HGNC:5384
OMIM 601149
CCDS CCDS10297
HPRD 03094
IMGT
EMBL AC090260
GenPept
RNA Seq Atlas 3419