Version 5.4
| Homo sapiens Gene: IDH3A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-24462.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | IDH3A | ||||||||||||||||||
| Gene Name | isocitrate dehydrogenase 3 (NAD+) alpha | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000166411 | ||||||||||||||||||
| Encoded Proteins |
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) alpha
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 15:78131498-78171949 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q25.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Citric acid cycle (TCA cycle) pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
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| KEGG |
Citrate cycle (TCA cycle) pathway
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| INOH |
Citrate cycle pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.250616 Hs.595357 Hs.604929 Hs.659780 | ||||||||||||||||||
| RefSeq | NM_005530 XM_005254336 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS10297 | ||||||||||||||||||
| HPRD | 03094 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||