|Homo sapiens Gene: RFXAP|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||regulatory factor X-associated protein|
regulatory factor X-associated protein
|Useful resources||Stemformatics EHFPI ImmGen|
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 13:36819224-36829104|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Antigen processing and presentation pathway
Primary immunodeficiency pathway
|UniProt Splice Variant|
|EMBL||AK313912 AL159973 BC026088 CH471075 Y12812|
|GenPept||AAH26088 BAG36635 CAA73338 CAH71159 EAX08575|
|RNA Seq Atlas||5994|