Homo sapiens Gene: MRPS35
Summary
InnateDB Gene IDBG-24767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS35
Gene Name mitochondrial ribosomal protein S35
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000061794
Encoded Proteins
mitochondrial ribosomal protein S35
mitochondrial ribosomal protein S35
mitochondrial ribosomal protein S35
mitochondrial ribosomal protein S35
mitochondrial ribosomal protein S35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27710773-27756295
Strand Forward strand
Band p11.22
Transcripts
ENST00000081029 ENSP00000081029
ENST00000536569 ENSP00000437990
ENST00000538315 ENSP00000445390
ENST00000542791 ENSP00000437991
ENST00000542199 ENSP00000442137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042769 DNA damage response, detection of DNA damage
GO:0043043 peptide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YFD1
UniProt Splice Variant
Entrez Gene 60488
UniGene Hs.714076 Hs.742125
RefSeq NM_001190864 NM_021821
HUGO HGNC:16635
OMIM 611995
CCDS CCDS53769 CCDS8714
HPRD 11373
IMGT
EMBL AC009509
GenPept
RNA Seq Atlas 60488