Version 5.4
Homo sapiens Gene: USO1
Summary
InnateDB Gene IDBG-24772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USO1
Gene Name USO1 vesicle docking protein homolog (yeast)
Synonyms P115; TAP; VDP
Species Homo sapiens
Ensembl Gene ENSG00000138768
Encoded Proteins
IDBP-24774
USO1 vesicle docking protein homolog (yeast)
IDBP-594130
USO1 vesicle docking protein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:75724593-75814286
Strand Forward strand
Band q21.1
Transcripts
ENST00000264904 ENSP00000264904
ENST00000514213 ENSP00000444850
ENST00000512893
ENST00000508454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 50 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0016192 vesicle-mediated transport
GO:0045056 transcytosis
GO:0048211 Golgi vesicle docking
GO:0048280 vesicle fusion with Golgi apparatus
GO:0061025 membrane fusion
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029407
View Gene Order
ENSBTAG00000017028
Not yet available
Pathways
NETPATH
REACTOME
REACT_1100
Golgi Cisternae Pericentriolar Stack Reorganization pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt O60763
TrEMBL A0A024RDG1 S4R3X6
UniProt Splice Variant
Entrez Gene 8615
UniGene Hs.292689 Hs.739305 Hs.743258
RefSeq NM_001290049 NM_003715 XM_006714396 XM_006714397
HUGO HGNC:30904
OMIM 603344
CCDS CCDS75144
HPRD
IMGT
EMBL AC104828 AC110615 AK314289 AL832010 BC006398 BC032654 CH471057 D86326
GenPept AAH06398 AAH32654 BAA25300 BAG36947 CAD89917 EAX05749 EAX05750
RNA Seq Atlas 8615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca