Version 5.4
Homo sapiens Gene: ITSN1
Summary
InnateDB Gene IDBG-2505.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITSN1
Gene Name intersectin 1 (SH3 domain protein)
Synonyms ITSN; SH3D1A; SH3P17
Species Homo sapiens
Ensembl Gene ENSG00000205726
Encoded Proteins
IDBP-2507
intersectin 1 (SH3 domain protein)
IDBP-2509
intersectin 1 (SH3 domain protein)
IDBP-2515
intersectin 1 (SH3 domain protein)
IDBP-2517
intersectin 1 (SH3 domain protein)
IDBP-2519
intersectin 1 (SH3 domain protein)
IDBP-59190
intersectin 1 (SH3 domain protein)
IDBP-230649
intersectin 1 (SH3 domain protein)
IDBP-230651
intersectin 1 (SH3 domain protein)
IDBP-230653
intersectin 1 (SH3 domain protein)
IDBP-230655
intersectin 1 (SH3 domain protein)
IDBP-230657
intersectin 1 (SH3 domain protein)
IDBP-230659
intersectin 1 (SH3 domain protein)
IDBP-364105
intersectin 1 (SH3 domain protein)
IDBP-364219
intersectin 1 (SH3 domain protein)
IDBP-364260
intersectin 1 (SH3 domain protein)
IDBP-364261
intersectin 1 (SH3 domain protein)
IDBP-364263
intersectin 1 (SH3 domain protein)
IDBP-364268
intersectin 1 (SH3 domain protein)
IDBP-364269
intersectin 1 (SH3 domain protein)
IDBP-364278
intersectin 1 (SH3 domain protein)
IDBP-364280
intersectin 1 (SH3 domain protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33642400-33899861
Strand Forward strand
Band q22.11
Transcripts
ENST00000381318 ENSP00000370719
ENST00000381291 ENSP00000370691
ENST00000381285 ENSP00000370685
ENST00000381284 ENSP00000370684
ENST00000381283 ENSP00000370683
ENST00000379960 ENSP00000369294
ENST00000399367 ENSP00000382301
ENST00000399355 ENSP00000382292
ENST00000399353 ENSP00000382290
ENST00000399352 ENSP00000382289
ENST00000399349 ENSP00000382286
ENST00000399338 ENSP00000382275
ENST00000444491 ENSP00000400079
ENST00000451686 ENSP00000407132
ENST00000456489 ENSP00000411464
ENST00000419241 ENSP00000415302
ENST00000440794 ENSP00000396054
ENST00000437442 ENSP00000387377
ENST00000437126 ENSP00000413290
ENST00000428240
ENST00000420666 ENSP00000408319
ENST00000415023 ENSP00000409800
ENST00000470742
ENST00000488166
ENST00000474132
ENST00000465143
ENST00000487427
ENST00000472548
ENST00000479424
ENST00000462212
ENST00000495656
ENST00000475422
ENST00000489261
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 161 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019209 kinase activator activity
GO:0032947 protein complex scaffold
GO:0070064 proline-rich region binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048488 synaptic vesicle endocytosis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022957
View Gene Order
ENSBTAG00000021997
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
INOH
PID NCI
erbb1_internalization_pathway
Internalization of ErbB1
ephbfwdpathway
EPHB forward signaling
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt Q15811
TrEMBL C9J1A4 C9JXS9 D6PAW2 Q86VI9
UniProt Splice Variant
Entrez Gene 6453
UniGene Hs.160324 Hs.731910 Hs.90221
RefSeq NM_001001132 NM_003024 XM_005261026 XM_005261027 XM_005261031
HUGO HGNC:6183
OMIM 602442
CCDS CCDS33545 CCDS33546
HPRD 03898
IMGT
EMBL AF064243 AF064244 AF064245 AF064246 AF064247 AF114487 AF114488 AF180522 AK300274 AP000308 AP000309 AP000310 AP000311 AP000312 AP000313 AY254341 BC116186 BC117560 DQ386455 DQ679754 DQ679756 DQ679757 EU117382 EU120733 EU120734 EU120735 EU140799 EU140800 EU152331 GU939621 U61166
GenPept AAC50592 AAC78610 AAC78611 AAC80437 AAD29952 AAD29953 AAD53183 AAI16187 AAI17561 AAP13099 ABD72328 ABG74695 ABG74697 ABG74698 ABV21755 ABV24866 ABV24867 ABV24868 ABV58335 ABV58336 ABV69555 ADF97297 BAG62034
RNA Seq Atlas 102724664 6453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca