InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL9

Summary

InnateDB Gene

IDBG-25111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL9

Gene Name

chemokine (C-X-C motif) ligand 9

Synonyms

CMK; crg-10; Humig; MIG; SCYB9

Species

Homo sapiens

Ensembl Gene

ENSG00000138755

Encoded Proteins

IDBP-25113

chemokine (C-X-C motif) ligand 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21124994

CXCL9 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21124994

[Mus musculus] Cxcl9 exert direct antimicrobial effects in vitro against Bacillus anthracis spores and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity.

Entrez Gene

Summary

The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. [provided by RefSeq, Jul 2008]
This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:76001275-76007488

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000264888

ENSP00000354901

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0060326	cell chemotaxis