InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TERF1

Summary

InnateDB Gene

IDBG-25349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TERF1

Gene Name

telomeric repeat binding factor (NIMA-interacting) 1

Synonyms

hTRF1-AS; PIN2; t-TRF1; TRBF1; TRF; TRF1

Species

Homo sapiens

Ensembl Gene

ENSG00000147601

Encoded Proteins

IDBP-25351

telomeric repeat binding factor (NIMA-interacting) 1

IDBP-25353

telomeric repeat binding factor (NIMA-interacting) 1

IDBP-484834

telomeric repeat binding factor (NIMA-interacting) 1

IDBP-475568

telomeric repeat binding factor (NIMA-interacting) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:73008864-73048122

Strand

Forward strand

Band

q21.11

Transcripts

ENST00000276603	ENSP00000276603
ENST00000276602	ENSP00000276602
ENST00000518874	ENSP00000428838
ENST00000518695
ENST00000517390	ENSP00000430121
ENST00000522018
ENST00000518961
ENST00000520783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 330 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	331 [view]
Protein-Protein	327 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008301	DNA binding, bending
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000723	telomere maintenance
GO:0001309	age-dependent telomere shortening
GO:0007004	telomere maintenance via telomerase
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008156	negative regulation of DNA replication
GO:0010834	telomere maintenance via telomere shortening
GO:0031116	positive regulation of microtubule polymerization
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0032214	negative regulation of telomere maintenance via semi-conservative replication
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0051974	negative regulation of telomerase activity

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle