InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab7

Summary

InnateDB Gene

IDBG-253533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab7

Gene Name

RAB7, member RAS oncogene family

Synonyms

Rab7a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079477

Encoded Proteins

IDBP-140318

RAB7, member RAS oncogene family

IDBP-253535

RAB7, member RAS oncogene family

IDBP-253537

RAB7, member RAS oncogene family

IDBP-253539

RAB7, member RAS oncogene family

IDBP-253541

RAB7, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075785:
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:87999106-88045270

Strand

Reverse strand

Band

Transcripts

ENSMUST00000095048	ENSMUSP00000092658
ENSMUST00000113600	ENSMUSP00000109230
ENSMUST00000113598	ENSMUSP00000109228
ENSMUST00000113597	ENSMUSP00000109227
ENSMUST00000113596	ENSMUSP00000109226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006622	protein targeting to lysosome
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007174	epidermal growth factor catabolic process
GO:0007264	small GTPase mediated signal transduction
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0045022	early endosome to late endosome transport
GO:0045453	bone resorption
GO:0090383	phagosome acidification
GO:0090385	phagosome-lysosome fusion

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome
GO:0097208	alveolar lamellar body