Homo sapiens Gene: CCNG2
Summary
InnateDB Gene IDBG-25732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNG2
Gene Name cyclin G2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138764
Encoded Proteins
cyclin G2
cyclin G2
cyclin G2
cyclin G2
cyclin G2
cyclin G2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53%% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:77157151-77433388
Strand Forward strand
Band q21.1
Transcripts
ENST00000354403 ENSP00000346379
ENST00000316355 ENSP00000315743
ENST00000395640 ENSP00000379002
ENST00000502280 ENSP00000424665
ENST00000497512
ENST00000512918 ENSP00000426085
ENST00000509972 ENSP00000426476
ENST00000514756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000075 cell cycle checkpoint
GO:0007067 mitotic nuclear division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16589
TrEMBL D6RHI3
UniProt Splice Variant
Entrez Gene 901
UniGene Hs.740456
RefSeq NM_004354
HUGO HGNC:1593
OMIM 603203
CCDS CCDS3581
HPRD 04438
IMGT
EMBL AC008638 AC092674 AC104771 AC108144 AC112716 AF549495 AK292029 AK293899 BT019503 CH471057 CR542181 CR542200 L49506 U47414
GenPept AAC41978 AAC50689 AAN40704 AAV38310 BAF84718 BAG57286 CAG46978 CAG46997 EAX05812
RNA Seq Atlas 901