Version 5.4
Homo sapiens Gene: CCNG2
Summary
InnateDB Gene IDBG-25732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNG2
Gene Name cyclin G2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138764
Encoded Proteins
IDBP-25734
cyclin G2
IDBP-25736
cyclin G2
IDBP-239144
cyclin G2
IDBP-482636
cyclin G2
IDBP-475006
cyclin G2
IDBP-479992
cyclin G2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53%% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:77157151-77433388
Strand Forward strand
Band q21.1
Transcripts
ENST00000354403 ENSP00000346379
ENST00000316355 ENSP00000315743
ENST00000395640 ENSP00000379002
ENST00000502280 ENSP00000424665
ENST00000497512
ENST00000512918 ENSP00000426085
ENST00000509972 ENSP00000426476
ENST00000514756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000075 cell cycle checkpoint
GO:0007067 mitotic nuclear division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029385
View Gene Order
ENSBTAG00000021768
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.740456
RefSeq NM_004354
HUGO
OMIM
CCDS CCDS3581
HPRD 04438
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca