Homo sapiens Gene: CORO1A
Summary
InnateDB Gene IDBG-25839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CORO1A
Gene Name coronin, actin binding protein, 1A
Synonyms CLABP; CLIPINA; HCORO1; IMD8; p57; TACO;
Species Homo sapiens
Ensembl Gene ENSG00000102879
Encoded Proteins
coronin, actin binding protein, 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30182827-30189076
Strand Forward strand
Band p11.2
Transcripts
ENST00000219150 ENSP00000219150
ENST00000569203 ENSP00000454752
ENST00000565497 ENSP00000456457
ENST00000568982
ENST00000568763
ENST00000563778 ENSP00000456266
ENST00000570045 ENSP00000455552
ENST00000561815 ENSP00000456756
ENST00000566619
ENST00000562129
ENST00000564446
ENST00000561849
ENST00000569970 ENSP00000457509
ENST00000570244 ENSP00000457332
ENST00000564768
ENST00000569469
ENST00000567034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008092 cytoskeletal protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0001845 phagolysosome assembly
GO:0006816 calcium ion transport
GO:0006909 phagocytosis
GO:0006928 cellular component movement
GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008360 regulation of cell shape
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030833 regulation of actin filament polymerization
GO:0031589 cell-substrate adhesion
GO:0032796 uropod organization
GO:0034097 response to cytokine
GO:0042102 positive regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0048873 homeostasis of number of cells within a tissue
GO:0050870 positive regulation of T cell activation
GO:0050918 positive chemotaxis
GO:0051126 negative regulation of actin nucleation
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0001772 immunological synapse
GO:0001891 phagocytic cup
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030670 phagocytic vesicle membrane
GO:0030864 cortical actin cytoskeleton
GO:0031252 cell leading edge
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P31146
TrEMBL A0A024R611 H3BNA2 H3BRJ0 H3BU76
UniProt Splice Variant
Entrez Gene 11151
UniGene
RefSeq NM_007074 NM_001193333
HUGO HGNC:2252
OMIM 605000
CCDS CCDS10673
HPRD 05414
IMGT
EMBL AC012645 AF495470 AK314714 BC110374 BC126385 BC126387 CH471238 D44497 U34690 X89109
GenPept AAA77058 AAI10375 AAI26386 AAI26388 AAM18516 BAA07940 BAG37258 CAA61482 EAW79906 EAW79907 EAW79908 EAW79910
RNA Seq Atlas 11151