Version 5.4
Homo sapiens Gene: CORO1A
Summary
InnateDB Gene IDBG-25839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CORO1A
Gene Name coronin, actin binding protein, 1A
Synonyms CLABP; CLIPINA; HCORO1; IMD8; p57; TACO
Species Homo sapiens
Ensembl Gene ENSG00000102879
Encoded Proteins
IDBP-25841
coronin, actin binding protein, 1A
IDBP-750170
IDBP-753858
IDBP-753889
IDBP-749898
IDBP-750446
IDBP-746922
IDBP-746865
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30182827-30189076
Strand Forward strand
Band p11.2
Transcripts
ENST00000219150 ENSP00000219150
ENST00000569203 ENSP00000454752
ENST00000565497 ENSP00000456457
ENST00000568982
ENST00000568763
ENST00000563778 ENSP00000456266
ENST00000570045 ENSP00000455552
ENST00000561815 ENSP00000456756
ENST00000566619
ENST00000562129
ENST00000564446
ENST00000561849
ENST00000569970 ENSP00000457509
ENST00000570244 ENSP00000457332
ENST00000564768
ENST00000569469
ENST00000567034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008092 cytoskeletal protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0001845 phagolysosome assembly
GO:0006816 calcium ion transport
GO:0006909 phagocytosis
GO:0006928 cellular component movement
GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008360 regulation of cell shape
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030833 regulation of actin filament polymerization
GO:0031589 cell-substrate adhesion
GO:0032796 uropod organization
GO:0034097 response to cytokine
GO:0042102 positive regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0048873 homeostasis of number of cells within a tissue
GO:0050870 positive regulation of T cell activation
GO:0050918 positive chemotaxis
GO:0051126 negative regulation of actin nucleation
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0001772 immunological synapse
GO:0001891 phagocytic cup
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030670 phagocytic vesicle membrane
GO:0030864 cortical actin cytoskeleton
GO:0031252 cell leading edge
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030707
View Gene Order
ENSBTAG00000008631
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001193333 NM_007074
HUGO
OMIM
CCDS CCDS10673
HPRD 05414
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca