Version 5.4
Homo sapiens Gene: CLDN12
Summary
InnateDB Gene IDBG-25851.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN12
Gene Name claudin 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157224
Encoded Proteins
IDBP-25853
claudin 12
IDBP-241242
claudin 12
IDBP-241244
claudin 12
IDBP-381376
claudin 12
IDBP-381383
claudin 12
IDBP-483123
claudin 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90383721-90513402
Strand Forward strand
Band q21.13
Transcripts
ENST00000287916 ENSP00000287916
ENST00000394605 ENSP00000378103
ENST00000394604 ENSP00000378102
ENST00000416322 ENSP00000411399
ENST00000427904 ENSP00000391062
ENST00000451941
ENST00000496677 ENSP00000419053
ENST00000462636
ENST00000480135
ENST00000495768
ENST00000498033
ENST00000483862
ENST00000498326
ENST00000478752
ENST00000485696
ENST00000476475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046798
View Gene Order
ENSBTAG00000019486
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601185 Hs.603803 Hs.731917 Hs.741070
RefSeq NM_001185072 NM_001185073 NM_012129
HUGO
OMIM
CCDS CCDS5618
HPRD 13064
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca