Homo sapiens Gene: ACVR2B
Summary
InnateDB Gene IDBG-25934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACVR2B
Gene Name activin A receptor, type IIB
Synonyms ActR-IIB; ACTRIIB; HTX4;
Species Homo sapiens
Ensembl Gene ENSG00000114739
Encoded Proteins
activin A receptor, type IIB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:38453851-38493142
Strand Forward strand
Band p22.2
Transcripts
ENST00000352511 ENSP00000340361
ENST00000465020
ENST00000461232
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016362 activin receptor activity, type II
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0034711 inhibin binding
GO:0046872 metal ion binding
GO:0048185 activin binding
Biological Process
GO:0001501 skeletal system development
GO:0001702 gastrulation with mouth forming second
GO:0001822 kidney development
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009966 regulation of signal transduction
GO:0023014 signal transduction by phosphorylation
GO:0030073 insulin secretion
GO:0030324 lung development
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031016 pancreas development
GO:0032147 activation of protein kinase activity
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0035265 organ growth
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045669 positive regulation of osteoblast differentiation
GO:0048617 embryonic foregut morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0060021 palate development
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Regulation of signaling by NODAL pathway
Signal Transduction pathway
Signaling by BMP pathway
Signaling by NODAL pathway
Signaling by Activin pathway
KEGG
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001106 XM_005265583
HUGO
OMIM
CCDS CCDS2679
HPRD 04106
IMGT
EMBL
GenPept
RNA Seq Atlas