InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACVR2B

Summary

InnateDB Gene

IDBG-25934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR2B

Gene Name

activin A receptor, type IIB

Synonyms

ActR-IIB; ACTRIIB; HTX4

Species

Homo sapiens

Ensembl Gene

ENSG00000114739

Encoded Proteins

IDBP-25936

activin A receptor, type IIB

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:38453851-38493142

Strand

Forward strand

Band

p22.2

Transcripts

ENST00000352511	ENSP00000340361
ENST00000465020
ENST00000461232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016362	activin receptor activity, type II
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0034711	inhibin binding
GO:0046872	metal ion binding
GO:0048185	activin binding

Biological Process

GO:0001501	skeletal system development
GO:0001702	gastrulation with mouth forming second
GO:0001822	kidney development
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007368	determination of left/right symmetry
GO:0007389	pattern specification process
GO:0007498	mesoderm development
GO:0007507	heart development
GO:0009749	response to glucose
GO:0009791	post-embryonic development
GO:0009952	anterior/posterior pattern specification
GO:0009966	regulation of signal transduction
GO:0023014	signal transduction by phosphorylation
GO:0030073	insulin secretion
GO:0030324	lung development
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031016	pancreas development
GO:0032147	activation of protein kinase activity
GO:0032924	activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0035265	organ growth
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045669	positive regulation of osteoblast differentiation
GO:0048617	embryonic foregut morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0060021	palate development
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061298	retina vasculature development in camera-type eye