InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD1

Summary

InnateDB Gene

IDBG-25942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD1

Gene Name

frizzled family receptor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000157240

Encoded Proteins

IDBP-25944

frizzled family receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20667980

FZD1 has a role in the reciprocal regulation of the Toll-like receptor (TLR)/nuclear factor-kappaB (NF-kappaB) and the Wnt/beta-catenin pathway after aerosol infection of mice with Mycobacterium tuberculosis.

InnateDB Annotation from Orthologs

Summary

PMID 20667980

[Mus musculus] Fzd1 has a role in the reciprocal regulation of the Toll-like receptor (TLR)/nuclear factor-kappaB (NF-kappaB) and the Wnt/beta-catenin pathway after aerosol infection of mice with Mycobacterium tuberculosis. Fzd1 mRNA was significantly up-regulated during the course of infection in mice and its induction was dependent on TLRs, the myeloid differentiation response gene 88 (MyD88), and a functional NF-kappaB pathway.

Entrez Gene

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:91264364-91271326

Strand

Forward strand

Band

q21.13

Transcripts

ENST00000287934

ENSP00000287934

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001944	vasculature development
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030514	negative regulation of BMP signaling pathway
GO:0030855	epithelial cell differentiation
GO:0035414	negative regulation of catenin import into nucleus
GO:0035425	autocrine signaling
GO:0042493	response to drug
GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048286	lung alveolus development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060412	ventricular septum morphogenesis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell