Homo sapiens Gene: FZD1
Summary
InnateDB Gene IDBG-25942.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD1
Gene Name frizzled family receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157240
Encoded Proteins
frizzled family receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
FZD1 has a role in the reciprocal regulation of the Toll-like receptor (TLR)/nuclear factor-kappaB (NF-kappaB) and the Wnt/beta-catenin pathway after aerosol infection of mice with Mycobacterium tuberculosis.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Fzd1 has a role in the reciprocal regulation of the Toll-like receptor (TLR)/nuclear factor-kappaB (NF-kappaB) and the Wnt/beta-catenin pathway after aerosol infection of mice with Mycobacterium tuberculosis. Fzd1 mRNA was significantly up-regulated during the course of infection in mice and its induction was dependent on TLRs, the myeloid differentiation response gene 88 (MyD88), and a functional NF-kappaB pathway.
Entrez Gene
Summary Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:91264364-91271326
Strand Forward strand
Band q21.13
Transcripts
ENST00000287934 ENSP00000287934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001944 vasculature development
GO:0003149 membranous septum morphogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267 cell-cell signaling
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0008406 gonad development
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030514 negative regulation of BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0035414 negative regulation of catenin import into nucleus
GO:0035425 autocrine signaling
GO:0042493 response to drug
GO:0044338 canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339 canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048286 lung alveolus development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022 hard palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060412 ventricular septum morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032589 neuron projection membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Wnt lrp6 signalling [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Wnt signaling network
Cross-References
SwissProt Q9UP38
TrEMBL
UniProt Splice Variant
Entrez Gene 8321
UniGene Hs.706431 Hs.94234
RefSeq NM_003505
HUGO HGNC:4038
OMIM 603408
CCDS CCDS5620
HPRD 04558
IMGT
EMBL AB017363 AC084381 AF072872 BC051271 CH236949 CH471091
GenPept AAD41636 AAH51271 AAS02008 BAA34666 EAL24161 EAW76871
RNA Seq Atlas 8321