Homo sapiens Gene: MTERF
Summary
InnateDB Gene IDBG-25965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTERF
Gene Name mitochondrial transcription termination factor
Synonyms MTERF;
Species Homo sapiens
Ensembl Gene ENSG00000127989
Encoded Proteins
mitochondrial transcription termination factor
mitochondrial transcription termination factor
mitochondrial transcription termination factor
mitochondrial transcription termination factor
mitochondrial transcription termination factor
mitochondrial transcription termination factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:91692008-91880720
Strand Reverse strand
Band q21.2
Transcripts
ENST00000351870 ENSP00000248643
ENST00000406735 ENSP00000384986
ENST00000419292 ENSP00000414116
ENST00000456229 ENSP00000402175
ENST00000442961 ENSP00000395097
ENST00000425936 ENSP00000400966
ENST00000481516
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006353 DNA-dependent transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006390 transcription from mitochondrial promoter
GO:0006393 termination of mitochondrial transcription
GO:0010467 gene expression
GO:0032392 DNA geometric change
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial biogenesis pathway
Transcription from mitochondrial promoters pathway
Transcriptional activation of mitochondrial biogenesis pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
Mitochondrial transcription termination pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532216 Hs.595930 Hs.630457
RefSeq NM_001301134 NM_006980 XM_005250593 XM_006716126
HUGO
OMIM
CCDS CCDS5621 CCDS75629
HPRD 08373
IMGT
EMBL
GenPept
RNA Seq Atlas