Version 5.4
Mus musculus Gene: Kcnip3
Summary
InnateDB Gene IDBG-260417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnip3
Gene Name Kv channel interacting protein 3, calsenilin
Synonyms 4933407H12Rik; AI413860; Csen; DREAM; KChIP3; R74849
Species Mus musculus
Ensembl Gene ENSMUSG00000079056
Encoded Proteins
IDBP-204906
Kv channel interacting protein 3, calsenilin
IDBP-204908
Kv channel interacting protein 3, calsenilin
IDBP-204910
Kv channel interacting protein 3, calsenilin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115041:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127456498-127522094
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028850 ENSMUSP00000028850
ENSMUST00000103215 ENSMUSP00000099504
ENSMUST00000088538 ENSMUSP00000085896
ENSMUST00000137625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0015459 potassium channel regulator activity
GO:0043565 sequence-specific DNA binding
GO:0044325 ion channel binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0019233 sensory perception of pain
GO:0034765 regulation of ion transmembrane transport
GO:0043523 regulation of neuron apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032993 protein-DNA complex
GO:0043679 axon terminus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000115041
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_15
IL3 pathway
NetPath_23
TSH pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9QXT8
TrEMBL A2AHT3 Q3TMU2 Q3YAA9 Q3YAB0
UniProt Splice Variant
Entrez Gene 56461
UniGene
RefSeq NM_001111331 NM_001291005 NM_019789 XM_006499934
OMIM
CCDS CCDS16703 CCDS50703 CCDS71139
HPRD
IMGT
MGI ID MGI:1929258
MGI Symbol Kcnip3
EMBL AF184624 AF274050 AF287732 AF287733 AF287734 AF287735 AF287736 AF287737 AF300870 AK165711 AL731831 BC026980 BC047139 BC057329 DQ148499 DQ148500
GenPept AAF14576 AAF74784 AAG17450 AAH26980 AAH47139 AAH57329 AAK08175 AAK08176 AAK08177 AAK08179 AAK08180 AAZ77816 AAZ77817 BAE38349
RNA Seq Atlas 56461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca