Homo sapiens Gene: SEPT1
Summary
InnateDB Gene IDBG-26137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT1
Gene Name septin 1
Synonyms DIFF6; LARP; PNUTL3; SEP1;
Species Homo sapiens
Ensembl Gene ENSG00000180096
Encoded Proteins
septin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer\'s disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30378133-30395991
Strand Reverse strand
Band p11.2
Transcripts
ENST00000321367 ENSP00000324511
ENST00000566517
ENST00000572252 ENSP00000459780
ENST00000568577 ENSP00000456541
ENST00000563957
ENST00000567783
ENST00000570039
ENST00000563743
ENST00000573615
ENST00000562152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0005815 microtubule organizing center
GO:0030496 midbody
GO:0031105 septin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSLP pathway
REACTOME
KEGG
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632176
RefSeq NM_052838
HUGO
OMIM
CCDS CCDS10678
HPRD 15324
IMGT
EMBL
GenPept
RNA Seq Atlas