Homo sapiens Gene: MRPS28
Summary
InnateDB Gene IDBG-26311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS28
Gene Name mitochondrial ribosomal protein S28
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147586
Encoded Proteins
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:79918717-80030289
Strand Reverse strand
Band q21.13
Transcripts
ENST00000276585 ENSP00000276585
ENST00000522938 ENSP00000430858
ENST00000519386 ENSP00000428050
ENST00000521434 ENSP00000428880
ENST00000521605 ENSP00000427965
ENST00000519120 ENSP00000428744
ENST00000520946 ENSP00000430401
ENST00000518271 ENSP00000427846
ENST00000518371 ENSP00000476135
ENST00000522987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y2Q9
TrEMBL E5RFH3 E5RFT8 E5RGC7 E5RK86
UniProt Splice Variant
Entrez Gene 28957
UniGene Hs.521124
RefSeq NM_014018
HUGO HGNC:14513
OMIM 611990
CCDS CCDS6226
HPRD
IMGT
EMBL AB061209 AC009686 AC018952 AC036214 AF070663 AK315739 BC010150 CH471068
GenPept AAD20969 AAH10150 BAB54959 BAG38094 EAW87069
RNA Seq Atlas 28957