Version 5.4
Homo sapiens Gene: CTF1
Summary
InnateDB Gene IDBG-27219.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTF1
Gene Name cardiotrophin 1
Synonyms CT-1; CT1
Species Homo sapiens
Ensembl Gene ENSG00000150281
Encoded Proteins
IDBP-27221
cardiotrophin 1
IDBP-240412
cardiotrophin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30896607-30903560
Strand Forward strand
Band p11.2
Transcripts
ENST00000279804 ENSP00000279804
ENST00000395019 ENSP00000378465
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005146 leukemia inhibitory factor receptor binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0007517 muscle organ development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0048666 neuron development
GO:0048861 leukemia inhibitory factor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042340
View Gene Order
ENSBTAG00000017697
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q16619
TrEMBL
UniProt Splice Variant
Entrez Gene 1489
UniGene Hs.483811
RefSeq NM_001142544 NM_001330
HUGO HGNC:2499
OMIM 600435
CCDS CCDS10694 CCDS45464
HPRD
IMGT
EMBL AC135048 BC036787 BC064416 U43030 U43031 U43032 U43033
GenPept AAA85229 AAD12173 AAH36787 AAH64416
RNA Seq Atlas 1489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca