Version 5.4
Homo sapiens Gene: CA2
Summary
InnateDB Gene IDBG-27230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA2
Gene Name carbonic anhydrase II
Synonyms CA-II; CAC; CAII; Car2; HEL-76
Species Homo sapiens
Ensembl Gene ENSG00000104267
Encoded Proteins
IDBP-27232
carbonic anhydrase II
IDBP-480783
carbonic anhydrase II
IDBP-478757
carbonic anhydrase II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85463852-85481493
Strand Forward strand
Band q21.2
Transcripts
ENST00000285379 ENSP00000285379
ENST00000520127 ENSP00000428443
ENST00000520996
ENST00000518231
ENST00000522742 ENSP00000428947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001822 kidney development
GO:0002009 morphogenesis of an epithelium
GO:0006730 one-carbon metabolic process
GO:0009268 response to pH
GO:0010033 response to organic substance
GO:0010043 response to zinc ion
GO:0015701 bicarbonate transport
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032849 positive regulation of cellular pH reduction
GO:0038166 angiotensin-activated signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043627 response to estrogen
GO:0044070 regulation of anion transport
GO:0044281 small molecule metabolic process
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0046903 secretion
GO:0048545 response to steroid hormone
GO:0051453 regulation of intracellular pH
GO:0071498 cellular response to fluid shear stress
GO:2001150 positive regulation of dipeptide transmembrane transport
GO:2001225 regulation of chloride transport
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0043209 myelin sheath
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027562
View Gene Order
ENSBTAG00000017733
Not yet available
Pathways
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_121380
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_121329
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_120969
O2/CO2 exchange in erythrocytes pathway
REACT_111217
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04976
Bile secretion pathway
hsa04966
Collecting duct acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt P00918
TrEMBL V9HW21
UniProt Splice Variant
Entrez Gene 760
UniGene
RefSeq NM_000067
HUGO HGNC:1373
OMIM 611492
CCDS CCDS6239
HPRD 02023
IMGT
EMBL AK312978 BC011949 CH471068 CR536526 CR541875 FJ224289 J03037 M36532 M77176 M77177 M77178 M77179 M77180 M77181 X03251 Y00339
GenPept AAA51908 AAA51909 AAA51911 AAH11949 ACI45981 BAG35815 CAA27012 CAA68426 CAG38763 CAG46673 EAW87136
RNA Seq Atlas 760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca