InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCK

Summary

InnateDB Gene

IDBG-27657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCK

Gene Name

cholecystokinin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000187094

Encoded Proteins

IDBP-27659

cholecystokinin

IDBP-238072

cholecystokinin

IDBP-373327

cholecystokinin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:42257825-42266207

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000334681	ENSP00000335657
ENST00000396169	ENSP00000379472
ENST00000434608	ENSP00000409124
ENST00000484359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0001764	neuron migration
GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409	axonogenesis
GO:0008284	positive regulation of cell proliferation
GO:0032099	negative regulation of appetite
GO:0032461	positive regulation of protein oligomerization
GO:0042755	eating behavior
GO:0043065	positive regulation of apoptotic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051901	positive regulation of mitochondrial depolarization
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043194	axon initial segment
GO:0043195	terminal bouton
GO:0043203	axon hillock
GO:0043204	perikaryon