Homo sapiens Gene: CCK
Summary
InnateDB Gene IDBG-27657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCK
Gene Name cholecystokinin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187094
Encoded Proteins
cholecystokinin
cholecystokinin
cholecystokinin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:42257825-42266207
Strand Reverse strand
Band p22.1
Transcripts
ENST00000334681 ENSP00000335657
ENST00000396169 ENSP00000379472
ENST00000434608 ENSP00000409124
ENST00000484359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
GO:0001764 neuron migration
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008284 positive regulation of cell proliferation
GO:0032099 negative regulation of appetite
GO:0032461 positive regulation of protein oligomerization
GO:0042755 eating behavior
GO:0043065 positive regulation of apoptotic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051930 regulation of sensory perception of pain
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
GO:0043195 terminal bouton
GO:0043203 axon hillock
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P06307
TrEMBL Q6FG82
UniProt Splice Variant
Entrez Gene 885
UniGene Hs.458426
RefSeq NM_001174138 NM_000729
HUGO HGNC:1569
OMIM 118440
CCDS CCDS2696
HPRD 00321
IMGT
EMBL AK289716 AY514491 BC008283 BC093055 BC111026 BT006991 CH471055 CR542226 L00354
GenPept AAA53094 AAH08283 AAH93055 AAI11027 AAP35637 AAR89908 BAF82405 CAG47022 EAW64644 EAW64645
RNA Seq Atlas 885