InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP16

Summary

InnateDB Gene

IDBG-27856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP16

Gene Name

matrix metallopeptidase 16 (membrane-inserted)

Synonyms

C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP

Species

Homo sapiens

Ensembl Gene

ENSG00000156103

Encoded Proteins

IDBP-27858

matrix metallopeptidase 16 (membrane-inserted)

IDBP-476223

matrix metallopeptidase 16 (membrane-inserted)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:88032009-88328025

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000286614	ENSP00000286614
ENST00000522726	ENSP00000429147
ENST00000520568
ENST00000544227

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008047	enzyme activator activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001503	ossification
GO:0001958	endochondral ossification
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0035988	chondrocyte proliferation
GO:0043085	positive regulation of catalytic activity
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060348	bone development
GO:0097094	craniofacial suture morphogenesis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028226

View Gene Order

ENSBTAG00000006877

Not yet available

Pathways

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P51512

TrEMBL

E5RJA7

UniProt Splice Variant

Entrez Gene

4325

UniGene

Hs.492187 Hs.546267 Hs.609605 Hs.644848 Hs.712389

RefSeq

NM_005941

HUGO

HGNC:7162

OMIM

602262

CCDS

CCDS6246

HPRD

IMGT

EMBL

AB009303 AC037450 AC090575 AC090797 AC090980 AK314274 BC069500 BC075004 BC075005 CH471060 D83646 D83647 D85511 DQ003082

GenPept

AAH69500 AAH75004 AAH75005 AAX84515 BAA12022 BAA12023 BAA22226 BAA23742 BAG36934 EAW91651

RNA Seq Atlas

4325