Homo sapiens Gene: MMP16
Summary
InnateDB Gene IDBG-27856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP16
Gene Name matrix metallopeptidase 16 (membrane-inserted)
Synonyms C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP;
Species Homo sapiens
Ensembl Gene ENSG00000156103
Encoded Proteins
matrix metallopeptidase 16 (membrane-inserted)
matrix metallopeptidase 16 (membrane-inserted)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:88032009-88328025
Strand Reverse strand
Band q21.3
Transcripts
ENST00000286614 ENSP00000286614
ENST00000522726 ENSP00000429147
ENST00000520568
ENST00000544227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008047 enzyme activator activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001503 ossification
GO:0001958 endochondral ossification
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0035988 chondrocyte proliferation
GO:0043085 positive regulation of catalytic activity
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060348 bone development
GO:0097094 craniofacial suture morphogenesis
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51512
TrEMBL
UniProt Splice Variant
Entrez Gene 4325
UniGene Hs.492187 Hs.546267 Hs.609605 Hs.644848 Hs.712389
RefSeq NM_005941
HUGO HGNC:7162
OMIM 602262
CCDS CCDS6246
HPRD 03776
IMGT
EMBL AB009303 AK314274 BC069500 BC075004 BC075005 CH471060 D83646 D83647 D85511 DQ003082
GenPept AAH69500 AAH75004 AAH75005 AAX84515 BAA12022 BAA12023 BAA22226 BAA23742 BAG36934 EAW91651
RNA Seq Atlas 4325