Version 5.4
Homo sapiens Gene: NKTR
Summary
InnateDB Gene IDBG-27864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKTR
Gene Name natural killer-tumor recognition sequence
Synonyms p104
Species Homo sapiens
Ensembl Gene ENSG00000114857
Encoded Proteins
IDBP-27866
natural killer-tumor recognition sequence
IDBP-373541
natural killer-tumor recognition sequence
IDBP-373549
natural killer-tumor recognition sequence
IDBP-373551
natural killer-tumor recognition sequence
IDBP-812729
natural killer cell triggering receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:42600614-42648741
Strand Forward strand
Band p22.1
Transcripts
ENST00000232978 ENSP00000232978
ENST00000429888 ENSP00000404802
ENST00000442970 ENSP00000390259
ENST00000445842 ENSP00000408660
ENST00000468735
ENST00000460910
ENST00000487466
ENST00000459950
ENST00000478488
ENST00000465584
ENST00000466553
ENST00000498730
ENST00000472127
ENST00000460807
ENST00000508351
ENST00000464315
ENST00000472258
ENST00000490189
ENST00000617821 ENSP00000482143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016018 cyclosporin A binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032525
View Gene Order
ENSBTAG00000002795
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529509 Hs.715111
RefSeq NM_005385 XM_005265173 XM_005265174 XM_005265176 XM_005265178 XM_006713172 XM_006713173 XM_006713174
HUGO
OMIM
CCDS CCDS2702
HPRD 01195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca