Homo sapiens Gene: CEBPD
Summary
InnateDB Gene IDBG-281563.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEBPD
Gene Name CCAAT/enhancer binding protein (C/EBP), delta
Synonyms C/EBP-delta; CELF; CRP3; NF-IL6-beta;
Species Homo sapiens
Ensembl Gene ENSG00000221869
Encoded Proteins
CCAAT/enhancer binding protein (C/EBP), delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CEBPD is involved in TLR8 mediated innate immune response by binding to C/EBP cis-acting elements within the TLR8 promoter increasing its transcriptional activity.
CEBPD is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
Entrez Gene
Summary The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:47736909-47739086
Strand Reverse strand
Band q11.21
Transcripts
ENST00000408965 ENSP00000386165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
Experimentally validated
Total 129 [view]
Protein-Protein 42 [view]
Protein-DNA 86 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Transcriptional regulation of white adipocyte differentiation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Validated transcriptional targets of deltaNp63 isoforms
IL6-mediated signaling events
Cross-References
SwissProt P49716
TrEMBL
UniProt Splice Variant
Entrez Gene 1052
UniGene Hs.741546
RefSeq NM_005195
HUGO HGNC:1835
OMIM 116898
CCDS CCDS6142
HPRD
IMGT
EMBL BC105109 CH471068 M83667 S63168
GenPept AAA59927 AAB27293 AAI05110 EAW86679
RNA Seq Atlas 1052