|Homo sapiens Gene: CEBPD|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CCAAT/enhancer binding protein (C/EBP), delta|
|Synonyms||C/EBP-delta; CELF; CRP3; NF-IL6-beta;|
CCAAT/enhancer binding protein (C/EBP), delta
|Useful resources||Stemformatics EHFPI ImmGen|
CEBPD is involved in TLR8 mediated innate immune response by binding to C/EBP cis-acting elements within the TLR8 promoter increasing its transcriptional activity.
CEBPD is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
|Genomic Location||Chromosome 8:47736909-47739086|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Developmental Biology pathway
Transcriptional regulation of white adipocyte differentiation pathway
Validated targets of C-MYC transcriptional repression
Validated transcriptional targets of deltaNp63 isoforms
IL6-mediated signaling events
|UniProt Splice Variant|
|EMBL||BC105109 CH471068 M83667 S63168|
|GenPept||AAA59927 AAB27293 AAI05110 EAW86679|
|RNA Seq Atlas||1052|