Version 5.4
Homo sapiens Gene: AP4M1
Summary
InnateDB Gene IDBG-281654.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP4M1
Gene Name adaptor-related protein complex 4, mu 1 subunit
Synonyms CPSQ3; MU-4; MU-ARP2; SPG50
Species Homo sapiens
Ensembl Gene ENSG00000221838
Encoded Proteins
IDBP-30648
adaptor-related protein complex 4, mu 1 subunit
IDBP-242369
adaptor-related protein complex 4, mu 1 subunit
IDBP-383193
adaptor-related protein complex 4, mu 1 subunit
IDBP-383194
adaptor-related protein complex 4, mu 1 subunit
IDBP-383195
adaptor-related protein complex 4, mu 1 subunit
IDBP-383197
adaptor-related protein complex 4, mu 1 subunit
IDBP-383198
adaptor-related protein complex 4, mu 1 subunit
IDBP-383199
adaptor-related protein complex 4, mu 1 subunit
IDBP-383200
adaptor-related protein complex 4, mu 1 subunit
IDBP-383204
adaptor-related protein complex 4, mu 1 subunit
IDBP-383206
adaptor-related protein complex 4, mu 1 subunit
IDBP-383207
adaptor-related protein complex 4, mu 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100101549-100110345
Strand Forward strand
Band q22.1
Transcripts
ENST00000359593 ENSP00000352603
ENST00000394061 ENSP00000377625
ENST00000429084 ENSP00000403663
ENST00000445208 ENSP00000400598
ENST00000438383 ENSP00000401613
ENST00000439416 ENSP00000414286
ENST00000446007 ENSP00000396928
ENST00000421755 ENSP00000412185
ENST00000416938 ENSP00000406106
ENST00000422582 ENSP00000406676
ENST00000450807 ENSP00000391585
ENST00000445295 ENSP00000393723
ENST00000478501
ENST00000463195
ENST00000495154
ENST00000479916
ENST00000489387
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0005802 trans-Golgi network
GO:0005905 coated pit
GO:0030119 AP-type membrane coat adaptor complex
GO:0030131 clathrin adaptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019518
View Gene Order
ENSBTAG00000002881
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632317 Hs.717689
RefSeq NM_004722 XM_005250689 XM_005250691
HUGO
OMIM
CCDS CCDS5685
HPRD 03803
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca