Version 5.4
Homo sapiens Gene: SCAF11
Summary
InnateDB Gene IDBG-28456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAF11
Gene Name SR-related CTD-associated factor 11
Synonyms CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP
Species Homo sapiens
Ensembl Gene ENSG00000139218
Encoded Proteins
IDBP-28458
SR-related CTD-associated factor 11
IDBP-101619
SR-related CTD-associated factor 11
IDBP-239507
SR-related CTD-associated factor 11
IDBP-239509
SR-related CTD-associated factor 11
IDBP-588843
SR-related CTD-associated factor 11
IDBP-587040
SR-related CTD-associated factor 11
IDBP-810505
SR-related CTD-associated factor 11
IDBP-587423
SR-related CTD-associated factor 11
IDBP-810510
SR-related CTD-associated factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22895188
Caspase-11 (SCAF11) increases susceptibility to Salmonella infection in the absence of caspase-1. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 22895188
[Mus musculus] Caspase-11 (SCAF11) increases susceptibility to Salmonella infection in the absence of caspase-1.
PMID 23348507
[Mus musculus] SCAF11 (Caspase 11) is required for innate surveillance against bacteria that escape the vacuole.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:45919131-45992120
Strand Reverse strand
Band q12
Transcripts
ENST00000266589 ENSP00000266589
ENST00000369367 ENSP00000358374
ENST00000395454 ENSP00000378840
ENST00000395453 ENSP00000378839
ENST00000465950 ENSP00000449812
ENST00000484275
ENST00000474828
ENST00000547654
ENST00000550629
ENST00000549162 ENSP00000448864
ENST00000550893 ENSP00000477742
ENST00000547950
ENST00000547018 ENSP00000446746
ENST00000546534
ENST00000551391 ENSP00000478596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033228
View Gene Order
ENSBTAG00000001810
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9169
UniGene
RefSeq NM_004719 XM_005269230 XM_006719692
HUGO HGNC:10784
OMIM 603668
CCDS CCDS8748
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 9169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca