Version 5.4
Homo sapiens Gene: TECPR1
Summary
InnateDB Gene IDBG-28493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TECPR1
Gene Name tectonin beta-propeller repeat containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205356
Encoded Proteins
IDBP-382550
tectonin beta-propeller repeat containing 1
IDBP-382555
tectonin beta-propeller repeat containing 1
IDBP-382559
tectonin beta-propeller repeat containing 1
IDBP-382561
tectonin beta-propeller repeat containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21575909
TECPR1 activity is necessary for efficient autophagic targeting of bacteria and the suppression of Shigella intracellular replication. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21575909
[Mus musculus] Tecpr1 activity is necessary for efficient autophagic targeting of bacteria and the suppression of Shigella intracellular replication.
Entrez Gene
Summary This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:98214624-98252251
Strand Reverse strand
Band q21.3
Transcripts
ENST00000447648 ENSP00000404923
ENST00000423128 ENSP00000407471
ENST00000415086 ENSP00000412675
ENST00000420697 ENSP00000396076
ENST00000490842
ENST00000463402
ENST00000485716
ENST00000462511
ENST00000474915
ENST00000479975
ENST00000476659
ENST00000479911
ENST00000483740
ENST00000471397
ENST00000463648
ENST00000472845
ENST00000488667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process
GO:0000046 autophagic vacuole fusion
GO:0006914 autophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000066621
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632303
RefSeq NM_015395 XM_005250253
HUGO
OMIM
CCDS CCDS47648
HPRD 08521
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca