Homo sapiens Gene: DSPP
Summary
InnateDB Gene IDBG-29145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSPP
Gene Name dentin sialophosphoprotein
Synonyms DFNA39; DGI1; DMP3; DPP; DSP; DTDP2;
Species Homo sapiens
Ensembl Gene ENSG00000152591
Encoded Proteins
dentin sialophosphoprotein
dentin sialophosphoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:87608529-87616910
Strand Forward strand
Band q22.1
Transcripts
ENST00000282478 ENSP00000282478
ENST00000399271 ENSP00000382213
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005518 collagen binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0007275 multicellular organismal development
GO:0030198 extracellular matrix organization
GO:0031214 biomineral tissue development
GO:0071460 cellular response to cell-matrix adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
ECM proteoglycans pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NZW4
TrEMBL B7SEY4 B7SEZ4
UniProt Splice Variant
Entrez Gene 1834
UniGene Hs.678914
RefSeq NM_014208
HUGO HGNC:3054
OMIM 125485
CCDS CCDS43248
HPRD
IMGT
EMBL AC093895 AF094508 AF163151 EU278638 EU278648 EU278653
GenPept AAD16120 AAF42472 ABX82466 ABX82476 ABX82481
RNA Seq Atlas 1834