Version 5.4
Homo sapiens Gene: FXC1
Summary
InnateDB Gene IDBG-29223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXC1
Gene Name fracture callus 1 homolog (rat)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132286
Encoded Proteins
IDBP-29225
fracture callus 1 homolog (rat)
IDBP-591192
fracture callus 1 homolog (rat)
IDBP-591421
fracture callus 1 homolog (rat)
IDBP-604056
fracture callus 1 homolog (rat)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6481447-6484679
Strand Forward strand
Band p15.4
Transcripts
ENST00000254616 ENSP00000254616
ENST00000528908
ENST00000530751 ENSP00000436579
ENST00000531462 ENSP00000433087
ENST00000533379 ENSP00000436948
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0007160 cell-matrix adhesion
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0042719 mitochondrial intermembrane space protein transporter complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000089847
View Gene Order
ENSBTAG00000003567
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z2B0
UniProt Splice Variant
Entrez Gene 26515
UniGene Hs.54943 Hs.702646 Hs.743551
RefSeq NM_012192
HUGO HGNC:4022
OMIM 607388
CCDS CCDS7766
HPRD 16242
IMGT
EMBL AC084337
GenPept
RNA Seq Atlas 26515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca