Homo sapiens Gene: DNAJA2
Summary
InnateDB Gene IDBG-29458.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJA2
Gene Name DnaJ (Hsp40) homolog, subfamily A, member 2
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2;
Species Homo sapiens
Ensembl Gene ENSG00000069345
Encoded Proteins
DnaJ (Hsp40) homolog, subfamily A, member 2
DnaJ (Hsp40) homolog, subfamily A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46955362-46973788
Strand Reverse strand
Band q11.2
Transcripts
ENST00000317089 ENSP00000314030
ENST00000563158 ENSP00000460104
ENST00000569553
ENST00000617000 ENSP00000477579
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0008284 positive regulation of cell proliferation
GO:0009408 response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL I3L320
UniProt Splice Variant
Entrez Gene 10294
UniGene Hs.368078 Hs.595856 Hs.701074 Hs.703099
RefSeq NM_005880
HUGO HGNC:14884
OMIM 611322
CCDS CCDS10726
HPRD 07105
IMGT
EMBL AC018845
GenPept
RNA Seq Atlas 10294