Version 5.4
Homo sapiens Gene: LARS2
Summary
InnateDB Gene IDBG-29537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARS2
Gene Name leucyl-tRNA synthetase 2, mitochondrial
Synonyms LEURS; PRLTS4
Species Homo sapiens
Ensembl Gene ENSG00000011376
Encoded Proteins
IDBP-29539
leucyl-tRNA synthetase 2, mitochondrial
IDBP-374271
leucyl-tRNA synthetase 2, mitochondrial
IDBP-374273
leucyl-tRNA synthetase 2, mitochondrial
IDBP-374274
leucyl-tRNA synthetase 2, mitochondrial
IDBP-374278
leucyl-tRNA synthetase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:45388506-45549421
Strand Forward strand
Band p21.31
Transcripts
ENST00000265537 ENSP00000265537
ENST00000415258 ENSP00000408576
ENST00000414984 ENSP00000412893
ENST00000431023 ENSP00000406611
ENST00000430399 ENSP00000401388
ENST00000467936
ENST00000485461
ENST00000474585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0010467 gene expression
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035202
View Gene Order
ENSBTAG00000007315
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.526975 Hs.613250 Hs.674494
RefSeq NM_015340 XM_005265006
HUGO
OMIM
CCDS CCDS2728
HPRD 05178
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca