Version 5.4
Homo sapiens Gene: DCHS1
Summary
InnateDB Gene IDBG-29545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCHS1
Gene Name dachsous 1 (Drosophila)
Synonyms CDH19; CDH25; CDHR6; FIB1; PCDH16; VMLDS1
Species Homo sapiens
Ensembl Gene ENSG00000166341
Encoded Proteins
IDBP-29547
dachsous 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6621323-6655854
Strand Reverse strand
Band p15.4
Transcripts
ENST00000299441 ENSP00000299441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0003007 heart morphogenesis
GO:0007156 homophilic cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
GO:0021915 neural tube development
GO:0022008 neurogenesis
GO:0035329 hippo signaling
GO:0036342 post-anal tail morphogenesis
GO:0043931 ossification involved in bone maturation
GO:0048565 digestive tract development
GO:0090102 cochlea development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036862
View Gene Order
ENSBTAG00000015405
Not yet available
Cross-References
SwissProt Q96JQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 8642
UniGene Hs.199850 Hs.593306
RefSeq NM_003737 XM_005253207
HUGO HGNC:13681
OMIM 603057
CCDS CCDS7771
HPRD
IMGT
EMBL AB000895 AB053446
GenPept BAA21133 BAB61903
RNA Seq Atlas 8642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca