Version 5.4
Homo sapiens Gene: PPM1K
Summary
InnateDB Gene IDBG-29590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1K
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1K
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163644
Encoded Proteins
IDBP-29592
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812318
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812319
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812320
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812324
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812326
protein phosphatase, Mg2+/Mn2+ dependent, 1K
IDBP-812317
protein phosphatase, Mg2+/Mn2+ dependent, 1K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88257620-88284769
Strand Reverse strand
Band q22.1
Transcripts
ENST00000295908 ENSP00000295908
ENST00000513546
ENST00000508256 ENSP00000476452
ENST00000510548 ENSP00000476789
ENST00000511506
ENST00000506423
ENST00000514204 ENSP00000477241
ENST00000505022 ENSP00000477051
ENST00000509340 ENSP00000477211
ENST00000608933 ENSP00000477341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037826
View Gene Order
ENSBTAG00000005754
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.43744
RefSeq NM_152542 XM_006714111
HUGO
OMIM
CCDS CCDS3629
HPRD 15167
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca