Homo sapiens Gene: F2R
Summary
InnateDB Gene IDBG-29671.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2R
Gene Name coagulation factor II (thrombin) receptor
Synonyms CF2R; HTR; PAR-1; PAR1; TR;
Species Homo sapiens
Ensembl Gene ENSG00000181104
Encoded Proteins
coagulation factor II (thrombin) receptor
coagulation factor II (thrombin) receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
A coagulation factor II (thrombin) receptor belonging to a family of G protein-coupled receptors, protease-activated receptors (PARs), and during inflammation, microorganisms as well as host immune cells release various proteases activating protease-activated receptors (PARs)
Activation of F2R stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells
F2R (PAR1) activates MAPK14 (p38) and MAPK3/1 (ERK1/2) kinases to trigger production of innate immunity markers in oral kertainocytes.
Entrez Gene
Summary Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76716043-76735781
Strand Forward strand
Band q13.3
Transcripts
ENST00000319211 ENSP00000321326
ENST00000505600 ENSP00000426398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0015057 thrombin receptor activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003105 negative regulation of glomerular filtration
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007262 STAT protein import into nucleus
GO:0007529 establishment of synaptic specificity at neuromuscular junction
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016265 death
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0032651 regulation of interleukin-1 beta production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0035025 positive regulation of Rho protein signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048873 homeostasis of number of cells within a tissue
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928 positive regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0060155 platelet dense granule organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070493 thrombin receptor signaling pathway
GO:1900134 negative regulation of renin secretion into blood stream
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016021 integral component of membrane
GO:0031094 platelet dense tubular network
GO:0031594 neuromuscular junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Thrombin signalling through proteinase activated receptors (PARs) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Endocytosis pathway
Complement and coagulation cascades pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Fibrinolysis pathway [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
PAR1-mediated thrombin signaling events
Cross-References
SwissProt
TrEMBL G3XAL6 Q6LCF1 Q71UT7
UniProt Splice Variant
Entrez Gene 2149
UniGene Hs.482562 Hs.679786
RefSeq NM_001992
HUGO HGNC:3537
OMIM 187930
CCDS CCDS4032
HPRD 01763
IMGT
EMBL AC025188 AF054633 CH471084 U63331
GenPept AAC25993 AAC50740 EAW95781
RNA Seq Atlas 2149