InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F2R

Summary

InnateDB Gene

IDBG-29671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2R

Gene Name

coagulation factor II (thrombin) receptor

Synonyms

CF2R; HTR; PAR-1; PAR1; TR

Species

Homo sapiens

Ensembl Gene

ENSG00000181104

Encoded Proteins

IDBP-29673

coagulation factor II (thrombin) receptor

IDBP-475871

coagulation factor II (thrombin) receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17977790

A coagulation factor II (thrombin) receptor belonging to a family of G protein-coupled receptors, protease-activated receptors (PARs), and during inflammation, microorganisms as well as host immune cells release various proteases activating protease-activated receptors (PARs)

PMID 11907122

Activation of F2R stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells

PMID 21029417

F2R (PAR1) activates MAPK14 (p38) and MAPK3/1 (ERK1/2) kinases to trigger production of innate immunity markers in oral kertainocytes.

Entrez Gene

Summary

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76716043-76735781

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000319211	ENSP00000321326
ENST00000505600	ENSP00000426398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0015057	thrombin receptor activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0002248	connective tissue replacement involved in inflammatory response wound healing
GO:0003105	negative regulation of glomerular filtration
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007262	STAT protein import into nucleus
GO:0007529	establishment of synaptic specificity at neuromuscular junction
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0009653	anatomical structure morphogenesis
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016265	death
GO:0030168	platelet activation
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032651	regulation of interleukin-1 beta production
GO:0032967	positive regulation of collagen biosynthetic process
GO:0035025	positive regulation of Rho protein signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048873	homeostasis of number of cells within a tissue
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport
GO:0051930	regulation of sensory perception of pain
GO:0060155	platelet dense granule organization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070493	thrombin receptor signaling pathway
GO:1900134	negative regulation of renin secretion into blood stream
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016021	integral component of membrane
GO:0031094	platelet dense tubular network
GO:0031594	neuromuscular junction
GO:0045211	postsynaptic membrane