InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SENP1

Summary

InnateDB Gene

IDBG-29677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SENP1

Gene Name

SUMO1/sentrin specific peptidase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000079387

Encoded Proteins

IDBP-373774

SUMO1/sentrin specific peptidase 1

IDBP-602495

SUMO1/sentrin specific peptidase 1

IDBP-593587

SUMO1/sentrin specific peptidase 1

IDBP-583725

SUMO1/sentrin specific peptidase 1

IDBP-589229

SUMO1/sentrin specific peptidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:48042898-48106308

Strand

Reverse strand

Band

q13.11

Transcripts

ENST00000448372	ENSP00000394791
ENST00000552189	ENSP00000447593
ENST00000549595	ENSP00000450076
ENST00000549518	ENSP00000447328
ENST00000551358
ENST00000547886
ENST00000551592
ENST00000551798	ENSP00000448597
ENST00000547181
ENST00000549882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0016925	protein sumoylation
GO:0016926	protein desumoylation
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033075

View Gene Order

ENSBTAG00000012423

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_163793

Processing and activation of SUMO pathway

REACT_17015

Metabolism of proteins pathway

REACT_163725

SUMO is proteolytically processed pathway

REACT_163823

SUMOylation pathway

KEGG

INOH

PID NCI

ar_tf_pathway

Regulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.371957 Hs.729657 Hs.733806 Hs.741874

RefSeq

NM_001267594 NM_001267595 XM_006719362

HUGO

OMIM

CCDS

CCDS44868

HPRD

07153

IMGT

EMBL

GenPept

RNA Seq Atlas