Homo sapiens Gene: IDH2
Summary
InnateDB Gene IDBG-29824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH2
Gene Name isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH;
Species Homo sapiens
Ensembl Gene ENSG00000182054
Encoded Proteins
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008]
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90083045-90102504
Strand Reverse strand
Band q26.1
Transcripts
ENST00000330062 ENSP00000331897
ENST00000560061 ENSP00000453254
ENST00000559482 ENSP00000453016
ENST00000540499 ENSP00000446147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Citrate cycle (TCA cycle) pathway
Glutathione metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YLL5
UniProt Splice Variant
Entrez Gene 3418
UniGene Hs.596461 Hs.737985
RefSeq NM_001290114 NM_002168 NM_001289910
HUGO HGNC:5383
OMIM 147650
CCDS CCDS10359
HPRD 00973
IMGT
EMBL AC087284 AC092769
GenPept
RNA Seq Atlas 3418