Version 5.4
Homo sapiens Gene: FYCO1
Summary
InnateDB Gene IDBG-29898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FYCO1
Gene Name FYVE and coiled-coil domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163820
Encoded Proteins
IDBP-29900
FYVE and coiled-coil domain containing 1
IDBP-374430
FYVE and coiled-coil domain containing 1
IDBP-374432
FYVE and coiled-coil domain containing 1
IDBP-587533
FYVE and coiled-coil domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:45917899-45995824
Strand Reverse strand
Band p21.31
Transcripts
ENST00000296137 ENSP00000296137
ENST00000433878 ENSP00000388136
ENST00000438446 ENSP00000398517
ENST00000471739
ENST00000535325 ENSP00000441178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0072383 plus-end-directed vesicle transport along microtubule
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025241
View Gene Order
ENSBTAG00000015698
Not yet available
Cross-References
SwissProt
TrEMBL C9J2W6
UniProt Splice Variant
Entrez Gene 79443
UniGene Hs.200227 Hs.739775 Hs.743737
RefSeq NM_024513 XM_005265484 XM_006713333 XM_006713334 XM_006713335
HUGO HGNC:14673
OMIM 607182
CCDS CCDS2734
HPRD 06215
IMGT
EMBL AC099782
GenPept
RNA Seq Atlas 79443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca