InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM26

Summary

InnateDB Gene

IDBG-300948.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM26

Gene Name

tripartite motif containing 26

Synonyms

AFP; RNF95; ZNF173

Species

Homo sapiens

Ensembl Gene

ENSG00000234127

Encoded Proteins

IDBP-368421

tripartite motif containing 26

IDBP-368423

tripartite motif containing 26

IDBP-368436

tripartite motif containing 26

IDBP-368446

tripartite motif containing 26

IDBP-368450

tripartite motif containing 26

IDBP-368453

tripartite motif containing 26

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23438823

TRIM26 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:30184455-30213427

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000453195	ENSP00000391879
ENST00000437089	ENSP00000395491
ENST00000454678	ENSP00000410446
ENST00000416596	ENSP00000413673
ENST00000418026	ENSP00000387530
ENST00000434785	ENSP00000400920
ENST00000480999
ENST00000487829

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024457

View Gene Order

ENSBTAG00000035744

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.610540 Hs.731863

RefSeq

NM_001242783 NM_003449 XM_005249374 XM_005249375 XM_005249376 XM_005249377 XM_005249378 XM_005274887 XM_005274888 XM_005274890 XM_005274891 XM_005275022 XM_005275023 XM_005275025 XM_005275026 XM_005275452 XM_005275453 XM_005275455 XM_005275456 XM_006715180

HUGO

OMIM

CCDS

CCDS4678

HPRD

02901

IMGT

EMBL

GenPept

RNA Seq Atlas