Homo sapiens Gene: CKMT1A
Summary
InnateDB Gene IDBG-301792.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKMT1A
Gene Name creatine kinase, mitochondrial 1A
Synonyms CKMT; CKMT1; UMTCK;
Species Homo sapiens
Ensembl Gene ENSG00000223572
Encoded Proteins
creatine kinase, mitochondrial 1A
creatine kinase, mitochondrial 1A
creatine kinase, mitochondrial 1A
creatine kinase, mitochondrial 1A
creatine kinase, mitochondrial 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80%% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43692886-43699222
Strand Forward strand
Band q15.3
Transcripts
ENST00000434505 ENSP00000413165
ENST00000411750 ENSP00000398973
ENST00000457648 ENSP00000389806
ENST00000415044 ENSP00000401927
ENST00000413453 ENSP00000406577
ENST00000483604
ENST00000479938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006600 creatine metabolic process
GO:0016310 phosphorylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Creatine metabolism pathway
KEGG
Arginine and proline metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J6W7 C9JFS8 C9JT96
UniProt Splice Variant
Entrez Gene 548596
UniGene Hs.654988 Hs.672483
RefSeq NM_001015001
HUGO HGNC:31736
OMIM 123290 613415
CCDS CCDS32217
HPRD 18683
IMGT
EMBL AC011330
GenPept
RNA Seq Atlas 1159 548596